Visceral perception: sensory transduction in visceral afferents and nutrients

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Visceral perception: sensory transduction in visceral afferents and nutrients.

The possible mechanisms that may be involved in nutrient detection in the wall of the gastrointestinal tract are reviewed. There is strong functional and electrophysiological evidence that both intrinsic and extrinsic primary afferent neurones mediate mechano- and chemosensitive responses in the gastrointestinal tract. This review focuses on the extrinsic afferent pathways as these are the ones...

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VISCERAL PERCEPTION Visceral perception: sensory transduction in visceral afferents and nutrients

The possible mechanisms that may be involved in nutrient detection in the wall of the gastrointestinal tract are reviewed. There is strong functional and electrophysiological evidence that both intrinsic and extrinsic primary afferent neurones mediate mechanoand chemosensitive responses in the gastrointestinal tract. This review focuses on the extrinsic afferent pathways as these are the ones t...

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Visceral hypersensitivity is currently the most widely accepted mechanism responsible for abdominal pain. Inflammatory mediators are known to sensitise primary afferents and to recruit silent nociceptors. Recent evidence suggests that non-inflammatory mediators also have the potential to trigger visceral pain. This sequence of events may constitute part of an alerting system which prompts the c...

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Visceral pain is the most common reason for doctor visits in the US. Like somatic pain, virtually all visceral pain sensations begin with the activation of primary sensory neurons innervating the viscera and/or the blood vessels associated with these structures. Visceral afferents also play a central role in tissue homeostasis. Recent studies show that in addition to monitoring the state of the...

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ژورنال

عنوان ژورنال: Gut

سال: 2002

ISSN: 0017-5749

DOI: 10.1136/gut.51.suppl_1.i11